Propecia Finasteride: Side Effects, Uses, Dosage, Interactions, Warnings

In a 4-year placebo-controlled clinical trial with another 5α-reductase inhibitor AVODART (dutasteride), similar results for Gleason score 8-10 prostate cancer were observed (1% dutasteride vs 0.5% placebo). The clinical significance of these findings with respect to use of PROPECIA by men is unknown. 3.7% (57 patients) treated with PROSCAR 5 mg and 2.1% (32 patients) treated with placebo discontinued therapy as a result of adverse reactions related to sexual function, which are the most frequently reported adverse reactions. Finasteride is anFDA-approved pharmacologic agent for treating benign prostate hyperplasia and androgenic alopecia (male pattern hair loss) in men. Finasteride 5 mg was first used in 1992 to treat benign prostatic hyperplasia.

Rogaine Women’s

In the meantime, try to stave off further hair loss by treating your hair gently. Avoid brushing it excessively, using harsh coloring products, and hairstyles that pull on the hair (such as a tight bun). If you feel self-conscious about having thin hair or bald patches, consider wearing a scarf or wig while your hair grows back. Proscar (finasteride) is used to treat benign prostatic hyperplasia (enlarged prostate).

No developmental abnormalities were observed in the offspring of untreated females mated with finasteride-treated male rats that received approximately 488 times the RHD (based on AUC at animal dose of 80 mg/kg/day). Slightly decreased fertility was observed in male offspring after administration of about 20 times the RHD (based on AUC at animal dose of 3 mg/kg/day) to female rats during late gestation and lactation. No effects on fertility were seen in female offspring under these conditions. PROPECIA® is indicated for the treatment of male pattern hair loss (androgenetic alopecia) in MEN ONLY. No evidence of a tumorigenic effect was observed in a 24-month study in Sprague-Dawley rats receiving doses of finasteride up to 160 mg/kg/day in males and 320 mg/kg/day in females. These doses produced respective systemic exposure in rats of 888 and 2192 times those observed in man receiving the recommended human dose of 1 mg/day.

What are the possible side effects of Propecia?

Abnormal male genital development is an expected consequence when conversion of testosterone to 5α-dihydrotestosterone (DHT) is inhibited by 5α-reductase inhibitors. These outcomes are similar to those reported in male infants with genetic 5α-reductase deficiency. Women could be exposed to finasteride through contact with crushed or broken PROPECIA tablets or semen from a male partner taking PROPECIA. With regard to finasteride exposure through the skin, PROPECIA tablets are coated and will prevent skin contact with finasteride during normal handling if the tablets have not been crushed or broken. Women who are pregnant or may become pregnant should not handle crushed or broken PROPECIA tablets because of possible exposure of a male fetus.

Cytochrome P450-Linked Drug Metabolizing Enzyme System

In clinical studies with PROPECIA (finasteride, 1 mg) in men years of age, the mean value of serum prostate specific antigen (PSA) decreased from 0.7 ng/mL at baseline to 0.5 ng/mL at Month 12. Further, in clinical studies with PROSCAR (finasteride, 5 mg) when used in older men who have benign prostatic hyperplasia (BPH), PSA levels are decreased by approximately 50%. Other studies with PROSCAR showed it may also cause decreases in serum PSA in the presence of prostate cancer. These findings should be taken into account for proper interpretation of serum PSA when evaluating men treated with finasteride. Any confirmed increase from the lowest PSA value while on PROPECIA may signal the presence of prostate cancer and should be evaluated, even if PSA levels are still within the normal range for men not taking a 5α-reductase inhibitor. Non-compliance to therapy with PROPECIA may also affect PSA test results.

Treatment for thyroid-related hair loss usually involves being properly medicated for the condition. In most cases, getting your thyroid hormones adjusted will reverse the hair loss, though it may take several months for the hair to grow back. While prolonged thyroid diseasemay cause diffuse hair loss, it’s important to note that with treatment of your thyroid dysfunction, regrowth will typically occur (although it may take months and it may be incomplete).

• PROPECIA® is indicated for the treatment of male pattern hair loss (androgenetic alopecia) in MEN ONLY.
• The second is that Synthroid has a history, as physicians have been treating patients with hypothyroidism with Synthroid for over 65 years.
• And in many cases, to also pop the top off the bottle while they are at the pharmacy counter and look at the pills and make sure they have SYNTHROID embossed on those tablets.
• The program outlines the recommended dosing, highlights significant adverse effects, identifies contraindications, and elucidates the essential aspects of monitoring and managing potential toxicity.
• I go over with the patient there are treatment goals that are very important in the process.

In a study of finasteride 1 mg daily in healthy men, a median decrease in ejaculate volume of 0.3 mL (- 11%) compared with 0.2 mL (-8%) for placebo was observed after 48 weeks of treatment. Family history is very important when talking to these patients because there is a strong predisposition amongst family members in the primary setting to have another family member with hypothyroidism. One of the difficulties of the diagnosis of hypothyroidism is that the signs and symptoms are non-specific to the disease.

In clinical studies, single doses of finasteride up to 400 mg and multiple doses of finasteride up to 80 mg/day for three months did not result in adverse reactions. Until further experience is obtained, no specific treatment for an overdose with finasteride can be recommended. However, this study may not have included the critical period for finasteride effects on development of male external genitalia in the rabbit. Women should not handle crushed or broken PROPECIA tablets when they are pregnant or may potentially be pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. PROPECIA tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets are not broken or crushed see WARNINGS AND PRECAUTIONS, Use In Specific Populations and PATIENT INFORMATION.

Finasteride dosing information

Using Propecia may increase your risk of developing a serious form of prostate cancer. Using multivitamin with minerals together with levothyroxine may decrease the effects of levothyroxine. You should separate the administration of levothyroxine and multivitamin with minerals by at least 4 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. During the 4- to 6-year placebo- and comparator-controlled Medical Therapy of Prostatic Symptoms (MTOPS) study that enrolled 3047 men, there were 4 cases of breast cancer in men treated with PROSCAR but no cases in men not treated with PROSCAR.

Finasteride 5mg is effective at treating the symptoms and delaying the progression of BPH. Finasteride 1mg temporarily reverses hair loss in men with androgenetic alopecia (male synthroid sommeil pattern baldness). Sexual dysfunction has been reported in less than 10% of men who take finasteride. Finasteride has no affinity for the androgen receptor and has no androgenic, antiandrogenic, estrogenic, antiestrogenic, or progestational effects.